If Kittle does miss Sunday's game, he will join star running back Christian McCaffrey, who is currently on the Injured Reserve list with a calf injury and Achilles tendonitis. Wide receiver Deebo Samuel is also missing time following a calf injury he suffered in Week 2. Quarterback Brock Purdy is running low on targets to throw to.

Pregame analysis and predictions of the San Francisco 49ers vs. Los Angeles Rams NFL game to be played on September 22, 2024 on ESPN.

The Rams have their work cut out for them in Week 3 but they have a chance to upset the 49ers if they win these 5 matchups

The Rams and 49ers will have Adam Amin and Mark Sanchez on the call for the second consecutive week. Kickoff is set for 4:25 p.m. ET from SoFi Stadium in Inglewood.

See who's in and who's out for the Week 3 matchup between the San Francisco 49ers and Los Angeles Rams on September 22, 2024.

Just two games into the season, the Rams (0-2) are approaching desperate times as they prepare to face the San Francisco 49ers (1-1) Sunday afternoon at SoFi Stadium. The list of issues thus far for the Rams is probably as long as their injury report.

It appears the San Francisco 49ers are quickly seeing some of the adversity generated when a wide receiver misses all of training camp. Wide receiver Brandon Aiyuk and quarterback Brock Purdy haven't been able to get on the same page in the 49ers' first two games.

Brandon Aiyuk’s stat line was not impressive against the Minnesota Vikings, but the 49ers wide receiver said he could see noticeable improvements from the 2024 NFL season opener. “I was happy watching tape this week,