This journal collection focuses on the pivotal roles of key immune cells and processes in maintaining immune regulation and homeostasis throughout the human lifespan. Mechanisms of immune regulation, ...

“A consistent feature of aging across diverse species is the progressive accumulation of lipid droplets (nLDs) within the nuclear compartment, which disrupts nuclear architecture and functionality.” ...

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis ...

The immune system exhibits remarkable plasticity, enabling dynamic responses to environmental cues while maintaining tissue homeostasis. Emerging evidence ...

Chronological aging is a major risk factor for many neurodegenerative disorders affecting both the brain and the eye, including Alzheimer’s disease, ...

As aging progresses, the quality of DNA and proteins inside cells declines, known to be the cause of various degenerative diseases. However, the connection between aging and RNA has remained largely ...

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on December 9, 2024, entitled "Nuclear lipid ...

Metabolic reprogramming and circadian disruption drive cellular senescence. Discover how repurposing vutiglabridin to target ...

Our overall goal is to understand circadian clock regulation of immune function in aging and disease. The circadian clock functions to synchronize physiological mechanisms within an organism with the ...