There is a huge and increasing body of experimental evidence for the importance of AMPA-type glutamate receptors in synaptic plasticity and learning, in both vertebrate and invertebrate organisms ...
The drugs now allow a detailed first assessment of CaMKII functions in any given system that's accessible to a wide range of scientists. Previous studies by Bayer's lab revealed that inhibiting CaMKII ...
As we learn, the structure of individual neurons in our brains change to strengthen important connections and weaken less important ones, a process known as structural plasticity. In Ryohei Yasuda's ...
"The amazing thing about CaMKII," Lisman says, "is that once you turn it on, it stays on more or less forever." In this sense, CaMKII "stores" memory. It becomes the molecule whose permanence ensures ...
As we learn, the structure of individual neurons in our brains change to strengthen important connections and weaken less important ones, a process known as structural plasticity. In Ryohei Yasuda's ...
To form and cement memories, the synapse must restructure itself, breaking down some proteins and rebuilding new configurations. The proteasome, which mediates the breakdown process, migrates into ...
Biochemists report how they used advanced sequencing technology to clear up uncertainty and determine all variants of a single protein/enzyme known as calcium/calmodulin-dependent protein kinase II ...
Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have captured real-time images showing how a key brain enzyme organizes itself to help memory formation. Their study, ...
The first calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor to be tested for prevention of post-MI heart failure stumbled in a small phase II trial. Among patients who had residual ...
The health impacts of a complex protein that plays a major role in the development of Alzheimer's disease and heart conditions can be lessened by three kinds of drug inhibitors, according to ...
AMHERST, Mass. - One of the new realities in biomedical research is that it's increasingly difficult to use a general approach to score advances. Now, investigations into disease mechanisms, for ...
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