The protein CaMKII is ubiquitous in cells throughout the body but is perhaps best known for its prominent role in the brain and the heart. It is critical in learning and memory, but if misregulated, ...

"The amazing thing about CaMKII," Lisman says, "is that once you turn it on, it stays on more or less forever." In this sense, CaMKII "stores" memory. It becomes the molecule whose permanence ensures ...

As we learn, the structure of individual neurons in our brains change to strengthen important connections and weaken less important ones, a process known as structural plasticity. In Ryohei Yasuda's ...

As we learn, the structure of individual neurons in our brains change to strengthen important connections and weaken less important ones, a process known as structural plasticity. In Ryohei Yasuda's ...

To form and cement memories, the synapse must restructure itself, breaking down some proteins and rebuilding new configurations. The proteasome, which mediates the breakdown process, migrates into ...

My research is on the “Impact of Mutations at CaMKII Threonine Sites on Drosophila melanogaster: Short-term Memory and Sleep Behavior.” CaMKII is suggested to play a huge role in both short-term and ...

When researchers use an inhibitor to block a kinase’s activity, they generally expect to see less of the downstream effects of that kinase. So when neuroscientists observed the opposite using a new ...

Synaptic plasticity is thought to be a key process for learning, memory and other cognitive functions of the nervous system. The initial events of plasticity require the conversion of brief electrical ...

The health impacts of a complex protein that plays a major role in the development of Alzheimer's disease and heart conditions can be lessened by three kinds of drug inhibitors, according to ...

Researchers are studying how proteins facilitate the plasticity of dendritic spines, the biological basis of learning and memory. They have developed a light-controllable tool to study the kinetics of ...

AURORA, Colo. (March 22, 2024) – The health impacts of a complex protein that plays a major role in the development of Alzheimer’s disease and heart conditions can be lessened by three kinds of drug ...