Many cancer-driving mutations disable a key checkpoint in the cell’s cycle between growth and division, resulting in unchecked activity of the E2F family of transcription factor proteins. A set of ...

The ability of mutations to cause cancer depends on how fast they force cells to divide, Sinai Health researchers have found. The study, led by Dr. Rod Bremner, a Senior Investigator at the ...

The review emphasizes how breakthroughs in understanding the molecular mechanisms of cell cycle regulation have paved the way for the development of targeted anti-cancer agents. Notably, inhibitors of ...