A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, offering fresh insight into how human cells build and maintain chromatin, ...

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, determines which genetic instructions are activated. When this fails, the wrong ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

The Dere lab specializes in kidney cancer and VHL (von Hippel Lindau) disease focused on understand fundamental aspects of how non-chromatin functions of chromatin modifiers contribute to oncogenesis.

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...