DNA methylation (*1) performs an essential function in mammalian ontogeny. It is also known that abnormalities in this process cause the development of cancers such as leukemia. A research team ...

Fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSCs) by the application of Yamanaka factors (OSKM), but the mechanisms underlying this reprogramming remain poorly understood.

(A) DNA methylation is maintained by DNMT1 on hemimethylated DNA after replication, while DNMT3A/3B catalyse de novo methylation on unmethylated DNA. In mammals, this modification is primarily found ...

A gene called DNMT3A is important for guiding blood stem cells into forming all the cell types present in blood, including red blood cells, white blood cells and platelets. When this gene accumulates ...