Observational studies are emerging as fundamental sources of information about vaccine effectiveness outside the controlled environment of randomized trials, and they are being used to generate ...

Comparative effectiveness research increasingly is being recognized as a priority area in cancer research. Although researchers have been conducting comparative effectiveness research for decades, ...

The 21st Century Cures Act also suggests that observational studies are critical in the approval process, even for new interventions. Our concern is that for interventions with risk of harm, ...