Epigenetic modifiers, enzymes that catalyze covalent modifications on chromatin, play a pivotal role in establishing stable states for gene expression and cellular identity. Mutations in these ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including ...

This method uses polymer modifications to tune enzyme activity for increased solubility in non-native solvents. Tuning the miscibility of enzymes in non-native solvent environments has important ...

Chemists use activity-based protein profiling (ABPP) to look for functional enzymes with specific activities, sometimes in hopes of finding leads for drug development. They search for these enzymes ...

Allyl isothiocyanate, the pungent principle of wasabi and other mustard oils, produces pain by activating TRPA1, an excitatory ion channel on sensory nerve endings. Isothiocyanates are ...