Researchers defined the structure of a substrate-bound iron 2-oxoglutarate (Fe/2OG) enzyme to explore whether these enzymes could be used to create a wide array of molecules. They saw that Fe/2OG ...

A team of biochemists at the University of California, Santa Cruz, has developed a faster way to identify molecules in the ...

The authors’ approach is deceptively simple: take an aldehyde dehydrogenase enzyme, which naturally converts aldehydes to acids, and get it to react with an amine instead of water. But actually making ...

Enzymology is the study of enzymes and enzyme-catalyzed reactions. Enzymes are biological catalysts that accelerate the rate of biological reactions. They can also perform multiple reactions ...

Reactions that can combine more than two molecular pieces in one go are a powerful way to build complexity quickly and save on costly isolation and purification. But the choreography for such a ...

Amide bonds are common in drugs because they are chemically stable, form readily and are biocompatible. They also help ...

Engineered enzymes are poised to have transformative impacts across applications in energy, materials, biotechnology, and medicine. Recently, machine learning has emerged as a useful tool for enzyme ...

An analysis of an unusual enzyme could result in a new generation of antimicrobial medicines to counter antibiotic resistance. Key details in the enzyme-driven biosynthesis of a natural molecule with ...