Researchers have found the closest thing to an off-switch for cancer: a specific protein section that has the ability to trigger the death of a cancer cell. A team from the UC Davis Comprehensive ...

A new study has discovered a promising approach to improve the efficacy of adoptive cell therapies for cancer. The research, published in Molecular Therapy: Nucleic Acids, describes the development of ...

A team of Memorial Sloan Kettering Cancer Center (MSK) researchers have made an important finding about why genetically engineered immune cells sometimes fail to finish the job when given as a cancer ...

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die ...

SADS, a new component of the Fas-mediated apoptotic pathway, is downregulated in patients with colon carcinoma. Could this dowregulation be a widespread mechanism of tumor cell immune evasion? (pages ...

A research team has identified a crucial mechanism on a specific cell receptor that can cause cells to self-destruct. Being able to activate the receptor -- Fas -- and trigger cell death could open ...

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Antigen-positive tumor cell (blue, left) is a direct target of CAR T-cells (light red) due to high-affinity antibody-antigen contacts. On the contrary, an antigen-negative tumor cell (light golden, ...