Dynamic light scattering is frequently utilized to assess the quality of protein aggregation, degradation and solution. However, for high-throughput screening, conventional dynamic light scattering ...

Drug discovery can be a long and complex process. Medicines for neurodegenerative diseases like Alzheimer's disease are among the most expensive to develop, as animal model results have not proven to ...

A team led by principal investigators Bobo Dang and Ting Zhou at Westlake University/Westlake Laboratory have developed a high-throughput platform for engineering fast-acting covalent protein ...

Fragment-based drug design (FBDD) has led to a revolution in contemporary drug discovery, facilitating a bottom-up approach to the identification and evolution of bioactive small molecules into viable ...

Modern laboratories rely on ultra-high-throughput screening (UHTS) to systematically evaluate chemical compounds or biological targets at massive scales. Depending on system configuration, these ...

CRISPR-based screening in drug discovery provides a robust methodology for unbiased, high-throughput interrogation of gene function. This technology enables researchers to identify and validate ...

Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) is a powerful technique for studying protein dynamics, however its widespread application has been constrained by high sample consumption and ...