Ras genes are commonly mutated in human cancers of the skin and other tissues. Oncogenic Ras signals through multiple effector pathways, including the Erk1/2 mitogen-activated protein kinase (MAPK), ...

Although clinical studies have evaluated several MEK1/2 inhibitors, it is unlikely that MEK1/2 inhibitors will be studied clinically. BRAF mutations have been proposed as a responder marker of MEK1/2 ...

Validating the woodchuck model for studying antiangiogenic therapies for human hepatocellular carcinoma (HCC). Background: MEK1/2 is an integral component of the Ras/Raf/MEK/ERK signaling pathway, ...

It was hypothesized that the MEK1/2 inhibitor ATR-002 could reduce inflammation and clear Staphylococcus aureus infection during cystic fibrosis, thus potentially showing a dual effect.

Sequential azacitidine and lenalidomide in elderly acute myeloid leukemia: completed results of the phase I study. Inotuzumab ozogamicin (IO; CMC544), a CD22 monoclonal antibody attached to ...

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Avian influenza viruses, particularly the H5 and H7 subtypes, can cause widespread outbreaks in birds and pose a significant zoonotic risk due to their potential to mutate and develop the ability for ...