Epithelial development, maintenance and repair requires that cells can divide and adapt to complex cell shape changes without dissociating their contacts with neighbouring cells and, hence, that they ...

A good yarn: chromosomes are shared out to dividing cells by mitotic spindles. Triesquid Cells use a tiny machine called the mitotic spindle to share genetic material equally between cells when they ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Zachary Gergely, Ammon Crapo, Loren Hough, J. Richard McIntosh, and Meredith D. Betterton (2016). Molecular Biology of the Cell27, 3490. arXiv DOI: 1604.08134. DOI ...

Scientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, ...

Mitosis is the process by which the genetic information encoded on chromosomes is equally distributed to two daughter cells, a fundamental feature of all life on earth. Scientists now examine how ...

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Yet, there are currently no highly effective therapies to treat patients with GBM and ~90% patients die within 2 years of ...

Spindle microtubules are yellow, with actin cytoskeletal filaments blue in this mitotic spindle. There is fresh recognition that cells' ability to build the structures that carry out cell division: ...

This is a fluorescence microscopy image of abnormal mitotic spindles in four breast cancer cells that were treated with antibody-linked maytansine. The chromosomes (blue) are not able to arrange in ...

Researchers from the Gerlich Group at IMBA—Institute of Molecular Biotechnology of the Austrian Academy of Sciences—discovered a molecular mechanism that confers special physical properties to ...

Paclitaxel is one of the most effective chemotherapy drugs for breast cancer. It is used for breast cancer in the early stages as well as for metastatic breast cancer, in combination with other ...