For Week 18 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 18 NFL schedule here. After analyzing every game in Week 18, the AI says the Rams (-7.5, 46.5), who have already clinched a postseason berth, cover comfortably against the Cardinals.

The Rams "need to play better football," so their starters will play, while the Eagles and Chargers are among those who will rest players.

Sam Farmer makes his picks and predictions for the final week of the NFL regular season, with the 49ers beat the Seahawks and the Steelers prevailing.

Picking the entire NFL slate in the final two weeks of the season is really challenging. Who is playing? Where's the motivation? Which players have their minds on Cancun and Aruba?  Those are my excuses for having a terrible Week 17.

This is it, football fan! The final week of the 2025-26 NFL regular season has arrived. Two games will take place on Saturday, another 14 will be played on Sunday, and that two-day stretch will put the finishing touches on this year's playoff field.

In just 24 hours, the final weekend of the 2025-26 NFL regular season will be officially underway, with a handful of playoff spots still up for grabs entering Week 18. On Saturday, the action kicks off with an afternoon doubleheader,