Clin Drug Invest. 2007;27(8):509-531. Antiretroviral drugs (ARVs) can be divided into four different classes according to their modes of action: nucleoside or nucleotide reverse transcriptase ...

A team of researchers has found a quicker and more efficient way to create nucleoside analogs, a type of small molecule that can be used in treatments for everything from cancer to viral diseases.

Pathogen recognition is based on the presence of Toll-like receptors (TLRs), which detect pathogen-associated molecular patterns (PAMPs) to coordinate the immune cascade. These receptors are encoded ...

The discovery of ArcS, which can utilize a nucleoside as a minimum substrate, provides new insights into the synthesis of precursor molecules for these modified nucleosides. The results of this ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

When we think about preparing for a healthy pregnancy and baby, most advice focuses on women. Such advice might include good nutrition, taking dietary supplements, avoiding alcohol or smoking and ...

If you’re living with HIV, there are now nine types of antiretroviral therapy (ART) that your doctor may prescribe medication AMong the most common are those called non-nucleoside reverse ...

DNA, often called the blueprint of life, is built from four chemical building blocks known as deoxy-nucleoside triphosphates (dNTPs)—dATP, dTTP, dGTP, and dCTP. Cells constantly need these molecules ...

Obeldesivir (GS-5245), a novel investigational small molecule oral antiviral, represents a new tool in the ongoing effort to prepare for future pandemics. Obeldesivir (GS-5245), a novel ...

A tiny percentage of our DNA—around 2%—contains 20,000-odd genes. The remaining 98%—long known as the non-coding genome, or so-called 'junk' DNA—includes many of the "switches" that control when and ...