Nature

Two-step amplification of the human PPT sequence provides specific gene expression in an immunocompetent murine prostate cancer model

The recombinant prostate-specific PPT sequence comprises a prostate-specific antigen enhancer, a PSMA enhancer and a TARP promoter. It is transcriptionally active in human prostate cancer cells both ...
Nature

Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad[I/PPT-E1A] by reduction of the insulator size and introduction of the full-length E3 region

Prostate cancer is the most common cancer among men in Europe and the United States, and the third most common cancer among men in the world. 1 The current therapies for localized prostate cancer are ...