Nature

Endothelin Signaling in Vascular Smooth Muscle Function

Endothelin signalling in vascular smooth muscle constitutes a central mechanism by which the endothelium regulates vascular tone, structure and remodelling. The 21-amino-acid peptide endothelin-1 ...
Medical Xpress

Study shows how sepsis can affect vascular smooth muscle cells on an acute and long-term basis

A recent study by University Medicine Halle shows how sepsis can lead to dysfunction of vascular smooth muscle cells. The researchers found that elevated lactate levels and acidosis, which can occur ...
Nature

Vericiguat prevents high glucose-mediated impaired vascular smooth muscle cGMP production and vasorelaxation

Normal endothelial cell dependent vascular smooth muscle cell function is mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of the second messenger cyclic ...