It's a mashup of performances from artists that few people would think of putting together, like R.E.M. and Morris Day, Rick James and Duran Duran, Hanson and Cher. Filmmaker Ahmir “Questlove” Thompson's experience as a DJ taught him enough about beats per minute and musical keys to meld things seamlessly.

The highly entertaining Ladies and Gentlemen gets into the best and most controversial musical moments from 50 years of SNL history. But what about the dregs?

Leslie Jones, Kate McKinnon, Seth Meyers, Molly Shannon, Kenan Thompson and Bowen Yang sit down with PEOPLE to talk about how they got to Studio 8H, their biggest laughs on the show and how hard it wa