First trial of concurrent amyloid and tau immunotherapies in sporadic Alzheimer’s is underway. Safety data are a go for subcutaneous remternetug. Plaque removal correlates with cognitive benefit in ...

All the things that define AD pathogenesis—the seeding and growth of Aβ plaques, withering of surrounding synapses, propagation of tau tangles, and infiltration of circulating immune cells into the ...

In addition, Eisai must conduct a post-authorization safety study, including setting up a patient registry for the European Union. Now each European country must set its own rules for access and ...

Tauopathies are a class of neurodegenerative disorders characterized by abnormal aggregation of the tau protein, encoded by the MAPT gene. These include frontotemporal dementia, Pick’s, and ...

The association between vaccination against the herpes zoster (HZ) virus, which causes shingles, and dementia risk continues to gain traction. Earlier this month, Pascal Geldsetzer and his team at ...

Talk about a closely watched study. Conference after conference, Roche scientists running the ongoing Brain Shuttle AD trial of trontinemab are dispensing morsels of news from sequential interim ...

As the trained killers of the immune system, cytotoxic T cells silently save our lives every day—vanquishing viruses before they can run amok, and putting nascent cancer cells out of business before ...

As lecanemab gains regulatory approval in more countries (see previous story), clinicians are eager to learn from the first centers to have incorporated this therapeutic antibody into their clinical ...

Cytotoxic T cells are star players in the adaptive immune system, enforcing protection against invading viruses or cancer cells. However, evidence has been mounting that the cells may also deal a ...

On April 15, two years after Eisai requested a marketing license for lecanemab in Europe, the European Commission has greenlit its use. The biologic’s long path included an initial rejection from the ...

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A biobank with fresh and formalin-fixed specimens specializing in neurogenerative disease research.