Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme (EC 4.2.1.11) that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the …

Enolase, also known as phosphopyruvate hydratase, was discovered in 1934 by Lohman and Mayerhof. It is one of the most abundantly expressed cytosolic proteins in many organisms.

Enolase is defined as a glycolytic enzyme involved in the synthesis of pyruvate, commonly referred to as alpha-enolase, and is recognized as a multifunctional protein with implications in …

Learn about the neuron-specific enolase (NSE) test, its role in diagnosing neuroendocrine tumors, brain injuries, and cancers. Discover normal ranges, results, and clinical significance.

1 day ago · Tailor et al. identify enolase 1 (ENO1) as the target of SU212, a promising therapeutic candidate for triple-negative breast cancer (TNBC). By inducing ENO1 degradation, SU212 …

Oct 31, 2025 · Glycolysis is crucial for maintaining cancer stemness. This study demonstrated the role of the glycolytic enzyme alpha-enolase (ENO1) in glycolysis and stemness in gastric …

Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 …

Enolase is located mainly in the cytosol of all eukaryotic cells where, besides its function in glycolysis and gluconeogenesis, it is also involved in regulation of cell morphology and …

Enolase(pdb = 1IYX) from Enterococcus hirae is an enzyme that participates in the glycolytic pathway by binding to 2-phosphoglyceric acid (PGA) and converting it to phosphoenol …

Oct 17, 2025 · Our findings suggest that an enolase 1 liquid blood biopsy could be used to support the detection of breast cancer at the earliest, most treatable, stage. Early diagnosis of …