"The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells".

WT-1 is a protein that acts as a transcription factor, meaning it helps control the activity of certain genes within cells. It was initially discovered because of its connection to Wilms’ tumour, a type of kidney …

Nov 14, 2025 · WT1 (WT1 Transcription Factor) is a Protein Coding gene. Diseases associated with WT1 include Wilms Tumor 1 and Denys-Drash Syndrome. Among its related pathways are Cell-cell …

The WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males) before birth. After birth, WT1 protein …

WT1 is a true chameleon, both acting as an oncogene and tumor suppressor. As its exact role in leukemogenesis is still ambiguous, research with model systems representing natural conditions …

Dec 1, 2023 · Wilms' tumor suppressor (WT1) gene is a transcription factor and an RNA-binding protein involved in the differentiation and survival of the cells of several organs, including the kidney and …

There is a specific gene known as WT1, located on chromosome 11 at position p13, which is altered in patients with the WT1 -related WT syndromes. The WT1 gene produces a protein known as a …

Jul 24, 2025 · WT1 carries the genetic instructions for producing a specific protein, which then carries out diverse functions within the body. Understanding this gene and its protein product is fundamental …

WT1-related syndromes are caused by changes in a gene known as WT1. WT1-related syndromes are hereditary. They can be passed from parents to their children. People with these conditions have a …

WT1 is overexpressed in a wide range of hematological and solid malignancies, including acute leukaemias where WT1 expression has prosgnostic significance. Therapeutic use: WT1 is proving to …