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3:31
YouTube
Pharmacology Animation
Proton Pump Inhibitors animation video
Proton pumps (H/K ATPase) in the parietal are the main regulator of gastric acidity. They excrete hydrogen into parietal cells in exchange of K ions. Gastrin, acetycholine and histamine H2 enhance the activity whereas prostaglandins E2 diminish the activity. Proton pump inhibitors like omeprazole directly inhibits the ptoton pums.
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